Hi,
we are facing the same issue since the cumulative Update for Windows 10 21H2 for x64 based Systems (KB5044273) has been rolled out to our new production line's PCs. This turned us crazy for a whole day until we tracked it down to the Windows update. We assume that a change in the .NET framework causes this by a difference in the SQL Client.
We are running it against a MariaDB 10.10 (x64) and are using MySQL ODBC 8.0 Unicode client.
Would be great if you could share the reply to your bug report herein also.